NEW YORK (Reuters Health) - babies born to women who take corticosteroids for asthma or other chronic headache may be drugs not an increased risk of birth defects, called labio, a study published Monday suggests.
"No drug can be proved 100% safe," lead researcher Dr. Anders Hviid, of Statens Serum Institute in Copenhagen, told Reuters Health by email. "However, our study supports that moderate to large in the slot increases risk can be excluded."
"This should reassure pregnant women and women planning pregnancy," he said.
The researchers found that among more than 800 000 babies born at the Denmark, it was no clear link between the use of the mothers of corticosteroids in early pregnancy and the risk of labio.
The findings establish non-there is no risk, experts say, but they should offer women some reassurance on their necessary medications.
Labial, cleft lip and cleft, is among the most common type of birth defect, affecting approximately 6 800 U.S. infants each year. Occur when the tissues forming the roof of the mouth and the upper lip fail to fuse properly, at some point between the fifth and the ninth week of pregnancy.
The causes of labial are not entirely clear, but a combination of environmental factors and genetic predisposition appears to be at work.
Some research involved drugs corticosteroids, which are widely used for asthma, eczema, other allergies and autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. Animal studies have suggested that drugs can cause labio, but if this is true of human beings remained uncertain.
The findings, which appear in the Canadian Medical Association Journal (CMAJ), are based on the data of all births in the Denmark between 1996 and 2008.
Among 832,636 births, there were 1.232 cases of cleft lip or palate. In all, 6% of mothers used corticosteroids during the first quarter - topical forms, by inhalation, oral or nasal-spray.
Researchers found no evidence that use of corticosteroids, in General, was linked to an increased risk of labio.
When they looked at different forms of medication, there was an association between topical corticosteroids - used for diseases of the skin such as eczema - and labio.
But researchers say, that seemed not to be a true link, but an "artifact" of the way in which their statistical analysis has been done. Hviid also stressed that the topical corticosteroids are among the least powerful forms, and "the conclusion does not any meaning from the biological perspective".
Dr. David Beuther, a lung specialist at the National Jewish Health in Denver, agreed that the results are reassuring.
"It goes with what we thought of the safety of steroids," said Beuther, who was not involved in the study.
Many people with asthma uses daily corticosteroids to control the condition and prevent asthma attacks. If women continue often on drugs during pregnancy, at the minimum dose required, according to Beuther.
"The most important thing," Reuters Health, he told "is." that their asthma is under good control
A serious asthma attack, said Beuther, would deprive the fetus of oxygen, which itself is a risk. In addition, prevent asthma attacks would allow pregnant women avoid using oral corticosteroids used to treat the.
With the oral form, the drug passes into the bloodstream, where he could cross the placenta. With corticosteroids, most of the drug does not reach the bloodstream, said Beuther.
There are still issues. This study does not address whether corticosteroids could be linked to another type of congenital malformation, Beuther stressed.
"We know that they are dangerous, but we cannot say that they are completely safe or", he said.
Beuther suggested that women who have concerns talk with their doctor - including comments that they are on the lowest dose of ICS to control their State.
Hviid agreed. "What is required will vary from woman to woman and should be discussed in detail with the physician," he said.
"In many cases,"Hviid said,"the real risks for the mother and the fetus to avoid treatment are greater than hypothetical risk of birth defects associated with treatment."
SOURCE: http://bit.ly/eXHQeS CMAJ, online on April 11, 2011.
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