The cells of the patient used to probe schizophrenia (AFP)

PARIS (AFP) - the skin cells are become tools of lab-dish to probe a more enigmatic and painful mind disorders, scientists reported Wednesday.

Researchers at the United States collected samples of cells of the skin of patients with schizophrenia and turned back to a primitive, versatile State called (iPSCs) induced pluripotent stem cells.

This blank slate, the cells were then grown to become the brain cells, allowing them to be used for surveys lab-dish in schizophrenia that can be adapted to the individual.

"Using this method, we can out how will affect a particular drug that brain cells of the patient in particular without the need of the patient to try the drug, and potentially suffer side effects," said Gong Chen of Penn State University in Pennsylvania.

"The patient may be his own Guinea pig for the design of its own processing, without having to be experienced on directly.".

Schizophrenia is a complex disease that is believed to have as hereditary environmental factors.

It is characterized by paranoid delusions and hallucinatory voices. Approximately one to % of the population in the world are expected to be affected by the disease.

Tests found that lab-dish neurons of patients with schizophrenia had less connections with other compared to cells from healthy individuals.

Scientists then used commonly prescribed antipsychotic drugs to see if this stimulated communication between neighbouring cells. The only one that worked was Loxapine, although it also has an effect of unexpected cascade hundreds of genes.

The work is reported online in Nature, the British scientific journal.

iPSCs were generated enormous enthusiasm because they were discovered in 2006. The idea is that they can be a test bed which is not the ethical burden of embryonic stem cells.

Some scientists in question, although if the iPSCs are biologically impeccable source. A study published in Nature in February found that the peripheral parts of their code, known as the epigenome, was marked with the reprogramming of errors.

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