Obesity treatment two effective drugs: study (AFP)

PARIS (AFP) - a new treatment of obesity that combines two existing drugs resulted in twice more than the loss of weight as the only approved drug anti-obesity in the long term, according to a study published Monday.

A mixture of Phentermine and topiramate, sold under the brand name of Topamax, has been shown in clinical trials twice as effective as orlistat, which is marketed in some countries such as Xenical or Alli, he said.

Drug combo seems to have additional benefits for the health improvement "markers", or, for blood pressure, levels of sugar, lipids and inflammation, she added.

Phentermine is the most widely prescribed drug of weight in the short term to the United States.

Topiramate is an anticonvulsant approved for the treatment of seizure disorders and migraine headaches. It has been shown that work well for weight in obese diabetic patients of type 2 loss, isolation - but - also has related to the cognitive and psychiatric side effects.

Lower doses taken with a mechanism for controlled release and in combination with other drugs would probably reduce these side effects, tests have shown.

Headed by Kishore Cadde of Duke University Medical Center in Durham in North Carolina the new trial was conducted on 20 months, with almost 2,500 overweight or obese adults at least two symptoms of major health risks.

Patients were divided into three groups.

A received a dose of 7.5 mg of Phentermine and topiramate 46 mg daily, while the second group was given 15 and 92 mg of the same drugs, respectively.

The third group received placebos lookalike.

After 56 weeks of treatment, the low dose group fell, on average, 8.1 kilograms (18 pounds) while that group of high dose hangar 10.2 kg (22 lb).

The patient, account required to placebos lose 1.4 kg (3.0 lbs).

Overall, 62 per cent of patients low dose lost at least five per cent of body weight, while 70% of the cohort of high doses crossed the same threshold.

The patient, account required to placebos lose 1.4 kg (3.0 lbs), with 21% detachment of five per cent of their total weight.

Two drug treatment was well tolerated, with only sporadic cases of dry mouth and constipation, according to the study, which is published by The Lancet.

The high dose group, however, have shown higher because of cognitive and psychiatric reactions abandonment undesirable.

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