(Friday, April 29, HealthDay News) - multiple pregnancies can increase the risk of obesity, diabetes and the build-up of plaque in arteries, suggests new research in mice.
Scientists from the University of Cincinnati and colleagues studied the mouse towards the end of gestation in both their first or fourth pregnancy. Those of their fourth pregnancy had severe glucose intolerance and adipose tissue excess, while those in their first pregnancy had no glucose intolerance and had less fat.
In addition, the adipose tissue of mice in their fourth pregnancy had significantly increased in several chemicals that cause inflammation called cytokines and accumulation of white blood cells called macrophages inflammation.
Cytokine changes repeated during pregnancy can cause residual inflammation that affects heart health, according to the study of.
If such changes occur also in humans, women who have multiple pregnancies can be at an increased risk of accumulation of plaque in arteries, obesity and diabetes, the researchers concluded.
The study was to be presented Friday to the American Heart Association arteriosclerosis, thrombosis and vascular biology 2011 scientific sessions in Chicago.
Because this study was presented at a medical meeting, the data and conclusions should be considered preliminary until published in a refereed journal.
More information
The March of Dimes describes the steps for a healthy pregnancy.
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