Loss of weight surgery may more likely low of Alzheimer's in diabetics (HealthDay)

(Sunday, June 5, HealthDay News) - while the finding is not conclusive, a new study suggests that surgery of the weight loss in obese diabetic may reduce their risk of developing Alzheimer's disease.

Researchers have found that patients of gastric bypass, the test of six months after their weight loss surgeries, less the expression of genes which are considered precursors of debris which obstructs the brains of people with Alzheimer's disease.

"Our study shows for the first time that the loss of weight resulting from Bariatric Surgery decreases the expression of genes associated with Alzheimer's disease," study author Dr. Paresh Dandona, Professor at the State University of New York at Buffalo, said in a press release of the endocrine society.

The study was to be presented Sunday at the annual meeting of the society in Boston. Research presented at meetings should be considered preliminary because it was not subject to the same level of review as studies published in most medical journals.

In the study, researchers analyzed the blood of the 15 patients with diabetes type 2, who had undergone weight loss surgery and an average of approximately 86 pounds lost more than six months. In relation to prior surgery, the expression of amyloid precursor protein patients dropped by 22 per cent, and researchers have noticed also less expression of other genes that appear to be related to Alzheimer's disease.

However, the study did not examine patients for signs of disease, so there is no way of knowing if their risk has actually declined.

Scientists believe there is a link between obesity and diabetes, which appears to increase the risk of Alzheimer's disease, said Greg Cole, Deputy Director of the Centre for Alzheimer's disease at the University of California at Los Angeles. He said that obesity can stimulate the inflammation in the body and brain.

"Weight loss is likely to improve the health, but a warning is that the epidemiology of weight loss is complicated," he added. Weight loss in the elderly may be a harbinger of incipient dementia. Moreover, according to a National Institute on Aging study, there may be significant differences in the way that the mid-life weight changes effect the risk for Alzheimer's disease: the women who lose weight between 30 and 45 appear to actually be at increased risk. ?

More information

For more information about Alzheimer's disease, visit the U.S. National Library of Medicine.

View the original article here